Saxenda

Do not use if you:

• Are allergic to liraglutide or any of the other ingredients in Saxenda.
• Have a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer).
• Have multiple endocrine neoplasia syndrome type 2 (MEN 2).
• Are pregnant, planning to become pregnant, or breastfeeding — Saxenda is not recommended during pregnancy as weight loss may harm an unborn baby.

Consult a doctor before use if you:

• Have a history of pancreatitis, gallbladder problems, or kidney disease.
• Are taking other medications for diabetes, as Saxenda may increase the risk of low blood sugar when combined with insulin or similar treatments.
• Have or are at risk of developing depression, anxiety, or suicidal thoughts.
• Have a history of heart problems, as your healthcare provider will need to assess whether Saxenda is appropriate for you.

Discontinue use and seek medical attention if:

• You experience severe or persistent stomach pain, nausea, or vomiting, which may be signs of pancreatitis.
• You notice a lump or swelling in your neck, hoarseness, or difficulty swallowing, which may indicate a thyroid problem.
• You experience symptoms of low blood sugar such as dizziness, confusion, sweating, or fainting.
• You develop signs of a serious allergic reaction, including swelling of the face, lips, or throat, or difficulty breathing.

Keep out of reach of children: Saxenda is a prescription medication and must only be used by the person for whom it has been prescribed.

Not for use in children or adolescents: Saxenda is not approved for use in individuals under 18 years of age and has not been studied in this age group.

Dosage:

Saxenda is administered as a once-daily injection, starting at a low dose of 0.6mg and gradually increasing over five weeks until reaching the recommended maintenance dose of 3mg. This slow escalation allows your body to adjust comfortably and helps minimise side effects.

Administration:

Inject Saxenda under the skin (subcutaneous injection) in the abdomen, thigh, or upper arm. Rotate your injection site with each dose to avoid skin irritation or soreness. Your healthcare provider will show you how to self-administer the pen correctly and safely.

Take with or without food:

Saxenda can be taken at any time of day, regardless of meals. For the best results, it should be used alongside a reduced-calorie diet and regular physical activity as part of a wider weight management programme.

Do not exceed the prescribed dose:

Always follow your healthcare provider's instructions carefully. If you miss a dose, take it as soon as you remember — unless your next dose is due within 12 hours, in which case skip the missed dose and continue as normal. Never take two doses at the same time to make up for a missed one.

Store properly:

Keep Saxenda in the refrigerator (2°C to 8°C) until you are ready to use it. Once in use, the pen can be stored at room temperature (below 30°C) or in the refrigerator for up to 30 days. Always keep the cap on when not in use and never freeze it.

Active Ingredient:

• Liraglutide (6mg/ml): A GLP-1 receptor agonist that mimics a natural hormone to regulate appetite, slow digestion, and help reduce overall food intake.

Inactive Ingredients:

• Disodium phosphate dihydrate
• Propylene glycol
• Phenol
• Water for injections
• Hydrochloric acid and/or sodium hydroxide (for pH adjustment)

These ingredients work together to ensure the stability, sterility, and effective delivery of Liraglutide with every dose.

Common Side Effects:

1. Nausea: Frequently reported, particularly during the first few weeks as your body adjusts to the medication.
2. Diarrhoea or constipation: Some digestive discomfort is normal when starting Saxenda and usually settles with time.
3. Vomiting: May occur as your appetite decreases and your eating habits begin to change.

Less Common but Serious Side Effects:

1. Pancreatitis: Symptoms include severe abdominal pain, nausea, and vomiting — stop taking Saxenda and seek immediate medical attention if these occur.
2. Gallbladder problems: Saxenda may increase the risk of gallstones, which can cause pain in the upper right abdomen or shoulder.
3. Low blood sugar (hypoglycaemia): More likely when Saxenda is used alongside other diabetes medications such as insulin or sulphonylureas.

Rare Side Effects:

1. Kidney problems: Persistent vomiting or diarrhoea can lead to dehydration, which may affect kidney function — contact your doctor if you notice reduced urine output or swelling in your hands or feet.
2. Thyroid tumours: Saxenda has been associated with thyroid tumours in rare cases — report any neck swelling, hoarseness, or difficulty swallowing to your doctor promptly.
3. Mood changes: Report any changes in mood, feelings of depression, or thoughts of self-harm to your healthcare provider immediately.

1. How often should I use Saxenda?

Saxenda is injected once daily, at any time of day, with or without food. Your doctor will guide you on the correct dose and schedule.

2. How much weight can I expect to lose with Saxenda?

Individual weight loss varies, but clinical studies have shown that Saxenda, combined with diet and exercise, can lead to significant weight reduction over several months.

3. Is Saxenda safe for long-term use?

Saxenda is approved for long-term use, but it is important to have regular check-ups with your healthcare provider to monitor progress and any potential side effects.

4. Can I take Saxenda if I have diabetes?

Yes, Saxenda can be used in individuals with type 2 diabetes, but it is not a treatment for diabetes. Your doctor will guide you on how to manage both conditions.

5. Are there any dietary restrictions while using Saxenda?

While there are no specific food restrictions, Saxenda should be used in conjunction with a calorie-controlled diet and regular exercise for best results.

6. Does Saxenda need to be refrigerated?

Yes, Saxenda should be stored in a refrigerator between 2°C and 8°C before first use. It should not be frozen. Once in use, it can be stored at room temperature below 30°C for up to 30 days.